Related Experiment Video

Updated: May 25, 2026

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
10:38

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

Published on: October 8, 2013

Does food intolerance play a role in recurrent respiratory papillomatosis?

Nalin J Patel1, Ali Jenzarli

  • 1Tampa Ear Nose and Throat Associates, Tampa, FL 33613, USA. pedsent@gmail.com

International Forum of Allergy & Rhinology
|February 8, 2012
PubMed
Abstract

Insights

Identifying food intolerances through oral food challenges helped achieve long-term remission in pediatric patients with recurrent respiratory papillomatosis (RRP). Dietary changes, alongside standard treatments, show promise for managing RRP.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pediatric Medicine

Background:

  • Recurrent respiratory papillomatosis (RRP) presents a management challenge, often requiring multiple surgical interventions.
  • The potential role of immune dysfunction and environmental factors, such as food intolerances, in RRP pathogenesis is under investigation.

Observation:

  • A retrospective review of 4 pediatric RRP cases managed between 2005 and 2010 was conducted.
  • Standard allergy testing (skin prick tests and RAST) did not identify IgE-mediated allergens.
  • Oral food challenges successfully identified specific food intolerances in all 4 patients.

Findings:

  • While standard allergy tests were inconclusive, detailed medical history and oral food challenges pinpointed specific food intolerances.
  • Implementing dietary elimination based on identified food intolerances, in conjunction with microdebrider resection and cidofovir injections, led to statistically significant long-term remissions.

Implications:

  • Food intolerances may play a significant role in the immune dysfunction associated with RRP.
  • Dietary modifications targeting identified food intolerances could be a beneficial adjunctive therapy for select pediatric RRP patients.
  • Further research into the link between food intolerances, immune responses, and RRP is warranted to optimize patient management.

More Related Videos

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Denver Papillae Protocol for Objective Analysis of Fungiform Papillae10:50

Denver Papillae Protocol for Objective Analysis of Fungiform Papillae

Published on: June 8, 2015

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.