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Protein Diffusion in the Membrane01:24

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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

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Published on: April 7, 2015

Restricted diffusion in vanishing white matter.

Hannemieke D W van der Lei1, Marjan E Steenweg, Marianna Bugiani

  • 1Departments of Pediatrics/Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.

Archives of Neurology
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

Restricted diffusion in vanishing white matter occurs in specific brain areas, particularly in younger patients with shorter disease duration. Histopathology shows these regions have higher cell density.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

  • Neuroimaging
  • Neuropathology
  • White Matter Diseases

Background:

  • Vanishing white matter (VWM) is a rare, inherited leukoencephalopathy.
  • Understanding the diffusion characteristics and histopathologic correlates of VWM is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the occurrence and location of restricted diffusion in VWM.
  • To determine the timing of restricted diffusion during the disease course.
  • To correlate imaging findings with histopathologic features.

Main Methods:

  • Retrospective observational study of 46 patients with VWM.
  • Analysis of diffusion-weighted imaging (DWI) to identify areas of restricted diffusion.
  • Measurement of apparent diffusion coefficients (ADCs) and correlation with age and disease duration.
  • Histopathologic examination of a postmortem VWM brain slice.

Main Results:

  • Restricted diffusion was observed in U fibers, cerebellar white matter, corpus callosum, and internal capsule.
  • Patients with restricted diffusion were younger and had shorter disease duration.
  • Histopathologic analysis revealed higher cell density in regions with restricted diffusion.

Conclusions:

  • Restricted diffusion in VWM is found in specific, often relatively spared, white matter regions.
  • These areas exhibit high cellularity, suggesting an active pathological process.
  • Early restricted diffusion may indicate a more favorable prognosis or a different disease stage.