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Arenavirus budding

Shuzo Urata1, Juan Carlos de la Torre

  • 1Department of Emerging Infectious Disease, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

Advances in Virology
|February 8, 2012
PubMed

Insights

Arenaviruses cause hemorrhagic fevers. The viral Z protein drives virus budding through L domain motifs, offering targets for new antiviral strategies against pathogenic arenaviruses.

Area of Science:

  • Virology
  • Molecular Biology
  • Infectious Diseases

Background:

  • Arenaviruses are significant public health threats, causing hemorrhagic fever diseases.
  • Lymphocytic choriomeningitis virus (LCMV) is a model arenavirus for studying virus-host interactions.
  • The arenavirus Z protein is crucial for viral budding.

Purpose of the Study:

  • To review current knowledge on arenavirus budding mechanisms.
  • To explore the diversity of late (L) domain motifs in arenavirus budding.
  • To discuss the potential of targeting viral budding for antiviral development.

Main Methods:

  • Literature review of arenavirus budding research.
  • Analysis of Z protein structure and function related to budding.
  • Comparative analysis of L domain motifs across different arenaviruses.

Main Results:

  • The Z protein is the primary driver of arenavirus budding.
  • Budding activity is mediated by specific C-terminal motifs: PT/SAP and PPXY.
  • Significant diversity exists in L domain motifs utilized by various arenaviruses.

Conclusions:

  • Understanding arenavirus budding provides insights into viral pathogenesis.
  • Knowledge of L domain motifs and Z protein function can guide antiviral drug design.
  • Targeting arenavirus budding represents a promising strategy against human pathogenic arenaviruses.

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