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[Water and electrolytes intestinal secretion (author's transl)]
La Nouvelle Presse Medicale
|February 17, 1979
Summary
This review explores intestinal fluid secretion in humans and animals, covering various stimuli and mechanisms. The adenylate-cyclase-cyclic adenosine monophosphate (AMPc) system is key, with both crypts and villi potentially involved in secretion.
Area of Science:
- Gastroenterology
- Physiology
- Molecular Biology
Background:
- Intestinal secretion is crucial for nutrient absorption and waste elimination.
- Understanding the regulation of intestinal fluid transport is vital for treating diarrheal diseases.
- Previous research has identified various factors influencing intestinal secretion.
Purpose of the Study:
- To review current methods for studying intestinal secretion.
- To discuss physiological and pathological factors affecting intestinal fluid secretion.
- To explore the mechanisms and cellular sites of intestinal secretion.
Main Methods:
- Literature review of studies on intestinal secretion in humans and animals.
- Analysis of data concerning fasting and postprandial secretion.
- Examination of secretion induced by enterotoxins, hormones, tumors, and intraluminary agents.
Main Results:
- Intestinal fluid secretion under physiological conditions is likely but not definitively proven.
- Multiple mechanisms contribute to intestinal fluid production.
- The adenylate-cyclase-cyclic adenosine monophosphate (AMPc) system plays a significant role in certain secretions.
Conclusions:
- Intestinal secretion is a complex process involving various stimuli and mechanisms.
- The AMPc system is implicated in enterotoxin and hormone-induced secretion.
- Both intestinal crypts and villi are potential sites for fluid secretion.