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Related Experiment Video

Updated: May 25, 2026

Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

Published on: September 29, 2023

Diversified carbohydrate-binding lectins from marine resources.

Tomohisa Ogawa¹, Mizuki Watanabe, Takako Naganuma

¹Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.

Journal of Amino Acids

|February 8, 2012

Summary

Marine lectins, proteins recognizing specific carbohydrates, show therapeutic potential. This review explores their structure-activity relationships and molecular evolution, focusing on key families like C-type lectins and galectins.

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Area of Science:

Marine biotechnology
Biochemistry
Molecular biology

Background:

Marine organisms are rich sources of bioactive molecules, including proteins like lectins.
Lectins are proteins that bind carbohydrates, playing roles in cell recognition, communication, and host-pathogen interactions.
Their ability to interact with specific glycoconjugates makes them promising for therapeutic applications.

Purpose of the Study:

To review marine-derived lectins, focusing on their structure-activity relationships.
To explore the molecular evolution of various marine lectin families.
To highlight unique properties of C-type lectins, galectins, F-type lectins, and rhamnose-binding lectins from marine sources.

Main Methods:

Literature review of studies on marine lectins.
Analysis of structure-activity relationships.
Examination of molecular evolution data for selected lectin families.

Main Results:

Marine lectins exhibit diverse structures and potent bioactivities.
Significant variations in structure-activity relationships were observed across different lectin families.
Molecular evolution provides insights into the functional diversification of marine lectins.

Conclusions:

Marine lectins represent a valuable resource for developing novel therapeutic agents.
Understanding their structural and evolutionary properties is crucial for harnessing their potential.
Further research into specific marine lectin families can unlock new biomedical applications.