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Polymorphism of flucloxacillin sodium
Xiao-Yin Zhou1, Zheng Liu, Miao-Miao Wang
1College of Chemical and Biological Engineering, Guilin University of Technology, Guilin, China.
Abstract:
The polymorphism of flucloxacillin sodium has not been discussed sufficiently so far. Flucloxacillin sodium which was crystallized with different solvents, was found to exist in amorphism and three crystal forms (I, II, III). This results were confirmed by infra-red (IR) spectra, thermogravimetry (TG), X-ray diffraction analysis (XRD) and equilibrium solubility. It is noticed that form III has very good solubility in phosphate buffer solution, with an average solubility of 0.86 g (20-40 degrees C). However, more efforts are needed to carry out and decide whether this form can be used for industrial production.
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