Contribution of pharmacokinetic computerized simulations in toxicological approach of ochratoxin A

An open two-compartment model described the fate of ochratoxin A in the rat. Curves of toxin quantities contained in the two compartments and predicted plasma concentrations following 1-, 2-, or 3-daily administrations were simulated by use of mathematical expressions programmed for a digital computer. These studies clearly showed residues of ochratoxin A in deep compartment tissues such as muscle, fat, and skin. The pharmacokinetic profiles of ochratoxin A in pigs and broilers were also investigated and discussed.