Related Experiment Video

Updated: May 25, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P53 and its molecular basis to chemoresistance in breast cancer

Stian Knappskog1, Per Eystein Lønning

  • 1Section of Oncology, Institute of Medicine, University of Bergen, 5020 Bergen, Norway.

Expert Opinion on Therapeutic Targets
|February 9, 2012
PubMed
Abstract

Insights

TP53 mutations are linked to anthracycline and mitomycin resistance in breast cancer. The p53 pathway

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • TP53 mutations are associated with resistance to anthracyclines and mitomycin in breast cancer.
  • This review explores the p53 cascade's role in drug resistance.

Purpose of the Study:

  • To examine the role of p53 pathway components in chemoresistance.
  • To investigate the impact of TP53 and related genes on breast cancer drug resistance.

Main Methods:

  • Literature search of ISI Web and PubMed.
  • Analysis of p53 activation, ATM/ATR, chk1/chk2, and MDM2/MDMX roles.
  • Review of TP53 isoforms and non-coding RNA in chemoresistance.

Main Results:

  • CHEK2 mutations predict anthracycline resistance in wild-type TP53 tumors.
  • MDM2/MDMX overexpression can inactivate p53 but lacks evidence in resistant breast cancers.
  • The roles of p53 isoforms and non-coding RNA in resistance are not yet defined.

Conclusions:

  • Disruptions in the p53 pathway are crucial in cancer chemoresistance.
  • TP53, like BRCA1/2, can serve as a 'beacon' for critical gene cascades in drug resistance.

More Related Videos

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...