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Updated: May 25, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
A clusterwise simultaneous component method for capturing within-cluster differences in component variances and
Kim De Roover1, Eva Ceulemans, Marieke E Timmerman
1Department of Educational Sciences, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium. Kim.DeRoover@ppw.kuleuven.be
Abstract:
This paper presents a clusterwise simultaneous component analysis for tracing structural differences and similarities between data of different groups of subjects. This model partitions the groups into a number of clusters according to the covariance structure of the data of each group and performs a simultaneous component analysis with invariant pattern restrictions (SCA-P) for each cluster. These restrictions imply that the model allows for between-group differences in the variances and the correlations of the cluster-specific components. As such, clusterwise SCA-P is more flexible than the earlier proposed clusterwise SCA-ECP model, which imposed equal average cross-products constraints on the component scores of the groups that belong to the same cluster. Using clusterwise SCA-P, a finer-grained, yet parsimonious picture of the group differences and similarities can be obtained. An algorithm for fitting clusterwise SCA-P solutions is presented and its performance is evaluated by means of a simulation study. The value of the model for empirical research is illustrated with data from psychiatric diagnosis research.
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