Related Experiment Video

Updated: May 25, 2026

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease
06:25

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Published on: March 29, 2024

Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers

Gökçe Güllü1, Sevgi Karabulut, Mustafa Akkiprik

  • 1Department of Medical Biology, School of Medicine, DMarmara University, Istanbul 34468, Turkey.

Chinese Journal of Cancer
|February 9, 2012
PubMed

Insights

Insulin-like growth factor-binding protein 5 (IGFBP5) influences cell growth, death, and motility, impacting cancer development. It shows promise as a clinical biomarker for cancer therapy response and outcomes.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Insulin-like growth factor-binding proteins (IGFBPs) regulate insulin-like growth factors (IGFs).
  • IGFBP5 possesses unique structural domains, including nuclear transport and heparin-binding motifs.
  • IGFBP5 mediates both IGF-dependent and IGF-independent effects on cellular processes.

Purpose of the Study:

  • To review the diverse functional roles of IGFBP5.
  • To explore the clinical significance of IGFBP5 in various cancers.
  • To highlight IGFBP5's potential as a predictive biomarker.

Main Methods:

  • Literature review of IGFBP5 functions and clinical relevance.
  • Analysis of IGFBP5's structural features and binding sites.
  • Examination of IGFBP5's role in cell growth, death, motility, and tissue remodeling.

Main Results:

  • IGFBP5 exhibits context-dependent functions influenced by cell type, tissue, and interacting proteins.
  • Its nuclear localization impacts biological effects.
  • Clinical studies indicate IGFBP5's utility in predicting cancer patient outcomes and therapy response.

Conclusions:

  • IGFBP5 is a multifaceted protein with significant roles in normal and cancerous cellular processes.
  • Its functional diversity is determined by cell-specific interactions and localization.
  • IGFBP5 holds considerable potential as a valuable biomarker in oncology.

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...