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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
A multicentre prospective study of post-traumatic endophthalmitis
Pierre-Loïc Cornut1, El Bichara Youssef, Alain Bron
1Department of Ophthalmology, Hôpital Edouard Herriot, Hospices Civils de Lyon, University Hospital, Université Lyon I, Lyon, France.
Acta Ophthalmologica
|February 9, 2012
Summary
Post-traumatic endophthalmitis outcomes depend on initial visual acuity and absence of retinal detachment. Staphylococcus epidermidis or culture-negative cases showed better visual recovery after ocular trauma.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Post-traumatic endophthalmitis is a severe intraocular infection following eye injury.
- Early diagnosis and appropriate management are crucial for visual preservation.
Purpose of the Study:
- To investigate the clinical and microbiological features of post-traumatic endophthalmitis.
- To identify prognostic factors influencing visual outcomes in these patients.
Main Methods:
- Prospective collection of clinical and microbiological data from 17 eyes with post-traumatic endophthalmitis (2004-2010).
- Analysis of aqueous and vitreous humor samples using conventional cultures and panbacterial PCR.
- Evaluation of treatment modalities, including pars plana vitrectomy, and their impact on visual acuity.
Main Results:
- Endophthalmitis signs appeared rapidly (1.5 ± 2.5 days post-trauma), often associated with intraocular foreign bodies (53%).
- Bacteria were detected in 77% of cases, with Staphylococcus epidermidis being the most common pathogen.
- Good final visual acuity (≥20/40) was linked to better initial visual acuity and absence of pupillary fibrin membrane; 41% achieved this outcome.
- Phthisis occurred in 35% of cases.
Conclusions:
- Initial visual acuity better than light perception and absence of retinal detachment are key indicators for favorable visual prognosis.
- Staphylococcus epidermidis and culture-negative endophthalmitis cases tend to have better visual outcomes.
- Bacterial virulence may correlate with poorer visual prognosis, warranting further investigation.
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