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Updated: May 25, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Difficulty in diagnosing oral paracoccidioidomycosis after topical nystatin usage
Felipe Fornias Sperandio1, Fernanda Salgueiredo Giudice, Ana Patricia Carneiro Goncalves Bezerra Coelho
1Department of Oral Pathology, University of Sao Paulo, SP, Brazil.
Abstract:
Paracoccidioidomycosis (PCM) is caused by a dimorphic fungus called Paracoccidioides brasiliensis and is a disseminated, systemic disorder that involves the lungs and other organs but presents characteristic oral lesions as the prominent feature. This article reports an unusual case of a 56-year-old man who had symptomatic granulomatous lesions in the oral cavity. The patient had received a nystatin-based treatment that masked the presence of fungi and made the diagnosis of PCM difficult. Although nystatin is normally used to treat oral fungal infections such as candidiasis, its topical usage is not appropriate for management of PCM. Once the patient received the correct treatment, he demonstrated a full recovery.
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