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MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study
Nicholas C Harvey1, Kassim Javaid, Nicholas Bishop
1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
Trials
|February 9, 2012
Summary
Mothers supplemented with vitamin D during pregnancy had offspring with higher bone mineral content at birth. This study explores the early origins of bone health and informs public health policy on prenatal vitamin D.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Public Health
Background:
- Osteoporosis is a significant public health concern linked to fragility fractures.
- Peak bone mass achieved in early adulthood is a predictor of later osteoporosis risk.
- Maternal vitamin D insufficiency during pregnancy is common and associated with reduced offspring bone mass.
Purpose of the Study:
- To investigate the impact of maternal vitamin D supplementation during pregnancy on offspring bone mass at birth.
- To test the early life origins hypothesis concerning skeletal development.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving pregnant women at three UK centers.
- Participants received either 1000 IU of oral vitamin D or placebo from 14 weeks of gestation.
- Offspring bone mass was assessed using DXA scans within 14 days of birth; follow-up included assessments at age 4.
Main Results:
- Offspring born to mothers supplemented with vitamin D exhibited higher whole-body bone mineral content adjusted for gestational age and age.
- Maternal vitamin D status and supplementation effects on fetal skeletal development were evaluated.
Conclusions:
- This trial provides evidence supporting vitamin D supplementation in pregnancy to enhance offspring bone mass.
- Findings have implications for public health policy regarding prenatal vitamin D intake.
- The study establishes a valuable resource for investigating other early life influences of maternal vitamin D status.
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