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Updated: May 25, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Contemporary management of overactive bladder.
1Division of Urology, University of Pennsylvania, Philadelphia, PA 19106, USA. ariana.smith@uphs.upenn.edu
Overactive bladder (OAB) management includes lifestyle changes, therapies, and medications. This review covers current and emerging treatments to improve quality of life for OAB patients.
Area of Science:
- Urology
- Nephrology
- Geriatrics
Background:
- Overactive bladder (OAB) is a common condition affecting quality of life.
- Many patients with OAB remain untreated or undertreated despite available options.
Purpose of the Study:
- To review contemporary management strategies for overactive bladder.
- To highlight new and developing treatments for OAB.
Main Methods:
- Review of current literature on overactive bladder treatments.
- Discussion of behavioral, physical, pharmacological, and procedural interventions.
- Analysis of recently approved and investigational therapies.
Main Results:
- Comprehensive management includes behavioral, pelvic floor muscle therapy, biofeedback, drug therapy, neuromodulation, and botulinum toxin.
- New drugs and therapies are now available, with more promising agents in development.
Conclusions:
- Effective management of overactive bladder requires a multi-faceted approach.
- Advances in treatment offer improved options for patients with overactive bladder.
- Ongoing research promises further therapeutic advancements for OAB.
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The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
