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Correlation of triglyceride level with acute coronary syndrome
Insights
This study found that higher serum triglyceride levels are significantly associated with acute coronary syndrome (ACS). Elevated triglycerides may aid in risk stratification and management of ACS patients.
Area of Science:
- Cardiology
- Biochemistry
- Public Health
Background:
- Acute coronary syndrome (ACS) is a leading cause of cardiovascular mortality.
- Serum triglyceride levels are a key component of lipid profiles and have been implicated in cardiovascular disease.
- Understanding the correlation between triglyceride levels and ACS is crucial for risk assessment and prevention strategies.
Purpose of the Study:
- To investigate the correlation between serum triglyceride levels and the incidence of acute coronary syndrome (ACS).
- To determine if elevated triglyceride levels serve as an independent risk factor for ACS.
- To explore the utility of triglyceride levels in the risk stratification of patients with ACS.
Main Methods:
- A cross-sectional study involving 100 participants (50 ACS patients and 50 healthy controls).
- Data collection included socio-demographic information, medical history, and laboratory investigations such as lipid profiles (including triglycerides, HDLc, LDLc), fasting blood sugar, ECG, and cardiac enzymes (troponin I).
- Statistical analysis utilized SPSS, employing Chi-square tests, t-tests, and ANOVA to assess significance and multivariate regression for risk assessment.
Main Results:
- The mean serum triglyceride level was significantly higher in ACS patients (168.2±58.0 mg/dl) compared to the control group (141.2±45.3 mg/dl) (p=0.01).
- Multivariate regression analysis indicated a significant association between elevated triglyceride levels and the risk of ACS (relative risk = 1.011, 95% CI = 1.002 - 1.020).
- The ratio of triglyceride to HDLc was a strong predictor of ACS (RR in the highest quartile vs. lowest quartile = 0.02, 95% CI = 0.003 - 0.173).
Conclusions:
- Elevated serum triglyceride levels are significantly associated with acute coronary syndrome.
- Triglyceride levels, particularly in relation to HDLc, can be valuable predictors for ACS risk.
- Categorizing patients based on serum triglyceride levels may enhance risk stratification and guide the management of ACS.
Abstract:
The study was aimed to find out the correlation of serum triglyceride level with acute coronary syndrome. This cross sectional study was conducted in the department of cardiology, Mymensingh Medical College Hospital, from August 2009 to May 2010. Socio-demographic characteristics, smoking habit, hypertension, serum total cholesterol level, serum HDLc, Serum LDLc, TG level were important variable considered. A total number of 100 respondents consisted of 50 cases (patient) and 50 healthy persons (control). Investigations included ECG, cardiac enzyme (troponin I), FBS and lipid profile. The data were analyzed by computer with the help of SPSS. Chi-square Test, T-test & ANOVA test were used as test of significance. The mean level of TG in acute coronary syndrome (ACS) patients (cases) was 168.2±58.0 mg/dl and in control were 141.2±45.3 mg/dl. So serum TG level is significantly higher in patients with ACS (p=0.01). In multivariate regression analysis, there was a significant association of elevated TG with risk of ACS (relative risk) is the highest, compared with the lowest quarantile = 1.011; 95% confidence interval (CI = 1.002 - 1.020; P for trend = 0.01). The relation of TG level to HDLc was a strong predictor of ACS (RR in the highest) compared with lowest quarantile = 0.02; (95% CI = 0.003 - 0.173; P for trend <0.0001). The study revealed that high level of serum triglyceride is associated with ACS. Categorization of patients with ACS on the basis of TG level may be helpful for risk stratification and management.
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