Related Experiment Video

Updated: May 25, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Acute hyperglycemia causes microvascular damage, leading to poor functional recovery and remodeling in patients

Katsuhiko Sarazawa1, Akira Nakano, Hiroyasu Uzui

  • 1First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui, Japan.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|February 9, 2012
PubMed

Insights

Acute hyperglycemia (AHG) in ST-segment elevation myocardial infarction (STEMI) patients impairs myocardial microcirculation, leading to worse outcomes. This study found AHG is linked to reduced myocardial flow reserve and poorer heart function recovery.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Imaging

Background:

  • Acute hyperglycemia (AHG) is linked to adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients.
  • The mechanisms by which AHG affects myocardial microcirculation in STEMI remain unclear.

Purpose of the Study:

  • To investigate the impact of AHG on myocardial microcirculation in STEMI patients undergoing reperfusion therapy.

Main Methods:

  • Thirty-four STEMI patients were categorized into groups with (Group H) or without (Group L) AHG.
  • Myocardial blood flow (MBF) and myocardial flow reserve (MFR) were assessed using ¹³N-ammonia positron emission tomography.
  • Wall motion abnormality scores (WMASs) and end-diastolic volume indices (EDVI) were evaluated at 1 and 6 months post-event.

Main Results:

  • Group H exhibited significantly lower MFR compared to Group L (P = .001).
  • WMAS was higher in Group H at both 1 and 6 months (P = .011 and P = .015, respectively).
  • Multivariate analysis identified AHG as an independent predictor of low MFR.

Conclusions:

  • AHG negatively impacts myocardial microcirculation in STEMI patients.
  • Impaired microcirculation due to AHG contributes to reduced functional recovery and adverse cardiac remodeling.
  • These findings highlight the importance of managing hyperglycemia in STEMI patients.
Abstract

Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...