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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Related Experiment Video

Updated: May 25, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Drug-induced pancreatitis.

Claudia Nitsche1, Sandrina Maertin, Jonas Scheiber

  • 1Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Friedrich-Loeffler-Strasse 23a, 17475 Greifswald, Germany.

Current Gastroenterology Reports
|February 9, 2012
PubMed
Summary

While many drugs can cause acute pancreatitis, definite causality is established for only 31 of 525 suspected medications. Further research is needed to clarify drug-induced pancreatitis incidence and causality.

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Last Updated: May 25, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Published on: June 28, 2021

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Toxicology

Background:

  • Drugs are suspected as a cause of acute pancreatitis, with 525 medications listed in the World Health Organization (WHO) database.
  • Many implicated drugs treat common diseases, suggesting a potential public health impact.
  • Existing data primarily comes from case reports and case-control studies, limiting understanding of true incidence.

Purpose of the Study:

  • To review the role of drugs as a cause of acute pancreatitis.
  • To assess the established causality for drug-induced acute pancreatitis.
  • To highlight the diagnostic challenges in identifying drug-induced pancreatitis.

Main Methods:

  • Analysis of data from the World Health Organization (WHO) database.
  • Review of existing literature, including case reports and case-control studies.
  • Application of the WHO classification criteria for establishing drug causality (rechallenge).

Main Results:

  • 525 drugs are suspected of causing acute pancreatitis.
  • Definitive causality has been established for only 31 of these drugs.
  • The diagnostic algorithm relies on excluding other causes and identifying the use of a suspected drug.

Conclusions:

  • Drug-induced acute pancreatitis is a significant concern, though causality is often difficult to establish.
  • A limited number of drugs have confirmed links to acute pancreatitis.
  • Accurate diagnosis requires careful consideration of medication history and exclusion of alternative etiologies.