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Updated: May 25, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Neoadjuvant chemotherapy for invasive bladder cancer
Guru Sonpavde1, Cora N Sternberg
1Michael E DeBakey Veterans Affairs Medical Center, Department of Medicine, Section of Medical Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Current Urology Reports
|February 9, 2012
Summary
Neoadjuvant chemotherapy improves outcomes for muscle-invasive bladder cancer by targeting early recurrences. This approach also allows for biomarker discovery and testing of new treatments.
Area of Science:
- Oncology
- Urology
- Cancer Research
Background:
- Muscle-invasive bladder cancer (MIBC) typically recurs early and distantly.
- Neoadjuvant chemotherapy is a standard treatment for resectable MIBC.
- Pathologic complete remission is a surrogate for survival in this setting.
Purpose of the Study:
- To explore the utility of neoadjuvant therapy in bladder cancer.
- To identify biomarkers predictive of treatment response.
- To evaluate novel biologic agents and combinations in the neoadjuvant setting.
Main Methods:
- Utilizing neoadjuvant cisplatin-based combination chemotherapy.
- Conducting baseline host and tumor tissue studies.
- Analyzing residual tumor post-neoadjuvant therapy.
Main Results:
- Neoadjuvant chemotherapy is established for resectable MIBC.
- Pathologic complete remission is an intermediate surrogate for survival.
- Baseline studies may identify predictive biomarkers.
Conclusions:
- The neoadjuvant setting is crucial for biomarker discovery and evaluating new agents.
- Residual tumor analysis can reveal mechanisms of action and resistance.
- Neoadjuvant therapy can accelerate the development of novel systemic agents for bladder cancer.
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