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Updated: May 25, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic
Casey M O'Dell1, Arabinda Das, Gerald Wallace
1Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Abstract:
Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE.
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