Related Experiment Video

Updated: May 25, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function--the Tromsø

Ellen E Brodin1, Sigrid K Brækkan, Anders Vik

  • 1Hematological Research Group (HERG), Department of Clinical Medicine, University of Tromsø, N-9037 Tromsø, Norway. ellen.brodin@uit.no

Haematologica
|February 9, 2012
PubMed

Insights

Serum cystatin C levels predict venous thromboembolism risk, even in individuals with normal kidney function. Higher cystatin C indicates a significantly increased risk of developing blood clots.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Thrombosis Research

Background:

  • Previous research linked impaired kidney function (eGFR) to venous thromboembolism (VTE).
  • Serum cystatin C is a marker for kidney function, but its independent association with VTE is less understood.

Purpose of the Study:

  • To investigate the association between serum cystatin C and VTE risk in individuals with normal kidney function.
  • To determine if cystatin C predicts VTE independently of kidney function.

Main Methods:

  • Prospective population-based study of 3251 adults (25-84 years) with normal kidney function (eGFR > 90 mL/min/1.73 m²).
  • Serum cystatin C levels measured; VTE events prospectively registered until September 1, 2007.
  • Cox-regression models used to calculate hazard ratios (HR) and 95% confidence intervals (CI).

Main Results:

  • A 1 SD increase in serum cystatin C correlated with a 43% increased VTE risk (HR 1.43; 95% CI 1.17-1.72).
  • Top quartile of cystatin C showed a 2.5-fold higher VTE risk (HR 2.51; 95% CI 1.27-4.96) versus the bottom quartile.
  • Risk was notably higher for provoked VTE (HR 3.11; 95% CI 1.23-7.86).

Conclusions:

  • Elevated serum cystatin C is associated with increased VTE risk in individuals with normal kidney function.
  • Findings suggest cystatin C may be a direct risk factor for venous thrombosis, not solely a marker of kidney impairment.
Abstract

More Related Videos

Venous Thrombosis Assay in a Mouse Model of Cancer04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...