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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: May 25, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Glaucoma and corneal transplant procedures.

Ammar M Al-Mahmood1, Samar A Al-Swailem, Deepak P Edward

  • 1Department of Ophthalmology, Ministry of Health, Manama 12, Bahrain.

Journal of Ophthalmology
|February 9, 2012
PubMed
Summary

Glaucoma following corneal transplantation, including penetrating keratoplasty and keratoprosthesis surgery, presents significant challenges. Management strategies must address incidence, etiology, and diagnostic difficulties to improve patient outcomes.

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Last Updated: May 25, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Area of Science:

  • Ophthalmology
  • Corneal Transplantation
  • Glaucoma Management

Background:

  • Glaucoma is a significant cause of visual impairment after corneal transplantation procedures.
  • The incidence and causes of post-keratoplasty glaucoma vary depending on the surgical technique used.
  • Existing glaucoma further complicates corneal transplant and keratoprosthesis surgeries.

Purpose of the Study:

  • To review the incidence, etiologies, and management of glaucoma after various corneal transplant procedures.
  • To highlight diagnostic and intraocular pressure monitoring challenges in these patients.
  • To discuss the impact of different corneal transplant types on glaucoma development.

Main Methods:

  • Literature review of studies on glaucoma after corneal transplantation.
  • Analysis of incidence rates and risk factors for different keratoplasty techniques.
  • Examination of current treatment options and their outcomes.
  • Discussion of diagnostic challenges and IOP monitoring in complex cases.

Main Results:

  • Post-keratoplasty glaucoma incidence is variable, with higher rates in penetrating keratoplasty and keratoprosthesis.
  • Surgical IOP control can lead to graft failure; deep anterior lamellar keratoplasty shows lower IOP elevation.
  • Descemet's stripping automated endothelial keratoplasty and keratoprosthesis present unique challenges, especially with prior glaucoma surgery.
  • Up to 75% of keratoprosthesis patients have glaucoma, often difficult to manage.

Conclusions:

  • Glaucoma is a common and complex complication of corneal transplantation, requiring tailored management.
  • Different corneal transplant procedures have distinct risks and challenges regarding secondary glaucoma.
  • Accurate diagnosis and IOP monitoring are crucial but often difficult in patients with post-keratoplasty glaucoma.