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Updated: May 25, 2026

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Pseudothrombocytopenia -- a caveat.

S K Sinha¹, Palash Kumar Mandal, Jayati Mallick

¹Department of Pathology, Medical College, Kolkata 700073.

Journal of the Indian Medical Association

|February 10, 2012

Summary

Pseudothrombocytopenia, a false low platelet count, is often missed by automated counters. Microscopic examination of blood smears is crucial to prevent unnecessary treatments and ensure accurate platelet counts.

Area of Science:

Hematology
Clinical Pathology
Laboratory Medicine

Background:

Pseudothrombocytopenia is an artifactual decrease in platelet count detected by automated analyzers.
It can be mistaken for true thrombocytopenia, leading to misdiagnosis and inappropriate treatments.
Reported incidences vary, potentially accounting for a significant portion of thrombocytopenia cases.

Purpose of the Study:

To investigate the causes and implications of pseudothrombocytopenia.
To emphasize the importance of accurate platelet count determination.
To highlight methods for preventing and identifying pseudothrombocytopenia.

Main Methods:

Review of automated cell counter principles and limitations.
Analysis of factors contributing to pseudothrombocytopenia in EDTA-anticoagulated blood.

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Microscopic examination of peripheral blood smears.

Consideration of direct counting methods in specific cases.

Main Results:

Common causes include improper EDTA blood storage (temperature, duration), excess EDTA, hyperlipidemia, and autoimmune conditions.
Automated counters may misclassify platelet clumps as leukocytes and fragmented red blood cells as platelets.
A significant percentage of cases (52%) had no apparent cause, underscoring diagnostic challenges.

Conclusions:

Direct microscopic examination of stained blood smears is essential before reporting platelet counts.
Proper sample handling, including EDTA blood ratio and storage, is critical.
Instrument calibration, reagent quality, and staff training are vital to minimize reporting errors, including pseudothrombocytopenia.