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06:29
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Primary cold agglutinin disease
Prabodh Chandra Mondal1, Partha Pratim Chakraborty, Mitali Bera
1Department of Paediatrics, Midnapore Medical College, Paschim Medinipur 721101.
Journal of the Indian Medical Association
|February 10, 2012
Summary
A child
Area of Science:
- Pediatrics
- Hematology
- Immunology
Background:
- Auto-immune hemolytic anemia (AIHA) is a rare condition.
- Cold agglutinin disease (CAD) is a subtype of AIHA.
- Prompt diagnosis and treatment are crucial for pediatric AIHA.
Observation:
- A 4-year-old girl presented with severe anemia and cola-colored urine.
- Peripheral blood smear showed red blood cell agglutination.
- The patient's serum tested positive for cold agglutinins.
Findings:
- The patient was diagnosed with primary cold agglutinin disease.
- Secondary causes of cold agglutinin disease were excluded through comprehensive testing.
- Corticosteroid therapy led to a successful clinical recovery.
Implications:
- This case highlights the importance of recognizing primary cold agglutinin disease in children.
- Early corticosteroid treatment can be effective for pediatric AIHA.
- Further research into the pathogenesis and optimal management of pediatric CAD is warranted.
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