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Updated: May 25, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Apparent diffusion coefficient values of necrotic and solid portion of lymph nodes: differential diagnostic value in
1Diagnostic Imaging and Intervening Center, Cancer Center, Guangzhou, Guangdong, PR China. zhangyun@sysucc.org.cn
Aim:
To evaluate whether the analysis of the apparent diffusion coefficient (ADC) values of the necrotic and solid portions of lymph nodes aids differentiation between the causes of cervical lymphadenopathy.
Materials And Methods:
Thirty-six patients with cervical lymph node metastasis from head and neck squamous cell carcinomas (SCC), 19 patients with lymphoma, and 23 patients with tuberculous lymphadenitis underwent conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI). The ADC values of necrotic and solid portions of lymph nodes were measured and compared. Receiver operating characteristic (ROC) analysis was employed to investigate whether ADC values could help to discriminate between the causes of cervical lymphadenopathy, and to obtain the optimal ADC threshold values.
Results:
The mean ADC values of the solid portions of metastatic nodes, lymphomatous nodes, and tuberculous nodes were (0.93±0.16)×10(-3)mm(2)/s, (0.64±0.13)×10(-3)mm(2)/s and (1.01±0.11)×10(-3)mm(2)/s, respectively (p<0.01). The mean ADC values of necrosis of metastatic and tuberculous nodes were (2.02±0.36)×10(-3)mm(2)/s and (1.25±0.15)×10(-3)mm(2)/s (p<0.01). By using the ADC value of the solid portion, the optimal ADC threshold values for distinguishing between metastasis and lymphoma, between metastasis and tuberculosis, and between lymphoma and tuberculosis were 0.77×10(-3), 0.98×10(-3) and 0.81×10(-3)mm(2)/s, respectively, and the sensitivities and specificities were 83 and 89%, 70 and 68%, 93 and 100%, respectively. By using ADC values of necrosis, the optimal ADC threshold value for distinguishing between metastasis and tuberculosis was 1.59×10(-3)mm(2)/s, and the sensitivity and specificity were 88 and 100%, respectively.
Conclusion:
The ADC values both of the necrotic and solid portions of the lymph nodes are useful in differentiation between the causes of cervical lymphadenopathy. The ADC value of necrosis is especially helpful in discriminating metastasis from tuberculosis.
