Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Late eating is associated with higher total energy intake and poorer adequacy of food groups in patients with non-communicable diseases.

Chronobiology international·2026
Same author

Greater fragmentation of the daily rhythm of energy intake is associated with better insulin sensitivity in rotating shift workers.

Chronobiology international·2026
Same author

Daily stress, sleep, fatigue and muscle soreness and their associations with injury and time loss in Para athletes: a 50-week prospective study.

BMJ open sport & exercise medicine·2026
Same author

Wrist temperature as a sleep marker in actigraphy.

Chronobiology international·2025
Same author

Late-eating adolescents consume more energy, make poorer dietary choices, and are more likely to have excess weight: An analysis of the Brazilian Household Budget Survey (2008-2009).

Chronobiology international·2025
Same author

Macronutrient-driven skin temperature responses in para-athletes: A randomized cross-over study using infrared thermography.

Clinical nutrition (Edinburgh, Scotland)·2025

Related Experiment Video

Updated: May 25, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Metabolic impact of shift work.

Ioná Zalcman Zimberg1, Silvio A Fernandes Junior, Cibele Aparecida Crispim

  • 1Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Work (Reading, Mass.)
|February 10, 2012
PubMed
Summary

Shift work is linked to higher rates of obesity and metabolic disorders like diabetes due to reduced sleep and circadian rhythm disruption. These factors contribute to serious health issues in shift workers.

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Related Experiment Videos

Last Updated: May 25, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Area of Science:

  • Occupational Health
  • Metabolic Science
  • Sleep Medicine

Background:

  • Shift work is common in developing nations, affecting a large workforce.
  • Shift workers exhibit higher prevalence of overweight/obesity compared to day workers.
  • Shift work is associated with increased risk of metabolic disorders including insulin resistance, diabetes, dyslipidemia, and metabolic syndrome.

Purpose of the Study:

  • To review the impact of shift work on obesity and metabolic disorders.
  • To explore the role of sleep disruption and circadian misalignment in these metabolic dysfunctions.

Main Methods:

  • Review of recent scientific literature and data.
  • Discussion of physiological and biological mechanisms.

Main Results:

  • Shift work is linked to increased overweight and obesity.
  • Common health effects include shortened or disturbed sleep.
  • Mechanisms involve autonomic nervous system activation, inflammation, and altered lipid/glucose metabolism.

Conclusions:

  • Sleep disruption and circadian misalignment are key contributors to metabolic dysfunction in shift workers.
  • Shift work poses significant risks for developing atherosclerosis, metabolic syndrome, and type II diabetes.