Related Experiment Video

Updated: May 25, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Preoperative high-sensitivity C-reactive protein predicts depression in patients undergoing coronary artery bypass

Limeng Yang1, Jianyang Wang, Lu Zhang

  • 1Department of Cardiovascular Surgery, State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

The Journal of Thoracic and Cardiovascular Surgery
|February 10, 2012
PubMed

Insights

Elevated high-sensitivity C-reactive protein (hsCRP) predicts depression risk in coronary artery bypass grafting (CABG) patients. This inflammation marker is linked to depression both before and up to six months after CABG surgery.

Area of Science:

  • Cardiology
  • Psychiatry
  • Biomarkers

Background:

  • Depression is a common comorbidity in patients undergoing coronary artery bypass grafting (CABG).
  • Preoperative inflammation, indicated by high-sensitivity C-reactive protein (hsCRP), may influence the risk of depression in these patients.

Purpose of the Study:

  • To investigate the association between preoperative high-sensitivity C-reactive protein (hsCRP) levels and the risk of depression in patients undergoing coronary artery bypass grafting (CABG).

Main Methods:

  • A cohort of 232 patients undergoing elective CABG were assessed for depression using the 9-item Patient Health Questionnaire scale preoperatively and at 6 months post-surgery.
  • Serum hsCRP levels were measured at baseline, and logistic regression analysis was used to identify predictors of depression.

Main Results:

  • The prevalence of depression was 18.1% preoperatively and postoperatively.
  • Preoperative depression was associated with female sex and elevated log-transformed hsCRP.
  • Postoperative depression was independently associated with log-transformed hsCRP, even after adjusting for medications and cardiovascular events.

Conclusions:

  • Elevated serum hsCRP is an independent predictor of depression in CABG patients, both before and up to six months after surgery.
  • hsCRP may represent a potential therapeutic target for improving the prognosis of CABG patients experiencing depression.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...