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[Antigenicity test of mofezolac (N-22)]
M Takemoto1, K Matsuo, S Katoh
1Daiichi Pure Chemicals Co., Ltd., Tokai Research Laboratories, Ibaraki, Japan.
The Journal of Toxicological Sciences
|June 1, 1990
Abstract:
Antigenicity studies of mofezolac (N-22) were examined in mice and guinea pigs and the following results were obtained. The findings of active systemic anaphylaxis, passive hemagglutination test, 4 hour passive cutaneous anaphylaxis (4-hr PCA) and 8-day PCA in guinea pigs revealed that N-22 possessed neither immunogenic nor eliciting potentiality. However, N-22 was shown to be eliciting antigenicity in mice when given N-22-ovalbumin conjugate plus Freund's complete adjuvant (FCA) as immunogen.