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Modulation of social influence by methylphenidate.

Daniel K Campbell-Meiklejohn1, Arndis Simonsen, Mads Jensen

  • 1Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark. dan.cfin@gmail.com

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|February 10, 2012
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Methylphenidate (MPH) increased social conformity by enhancing value perception alignment with group norms. This suggests MPH may modulate social learning and reduce disruptive behaviors by strengthening weak social signals.

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Published on: March 12, 2020

Area of Science:

  • Neuroscience
  • Social Psychology
  • Pharmacology

Background:

  • Social learning, or conformity, aligns individual values with group norms but its neurobiology is unclear.
  • Catecholamines are implicated in conformity, but empirical evidence is lacking.
  • Methylphenidate (MPH), a dopamine and noradrenaline agonist, is used to treat ADHD and may increase conformity.

Purpose of the Study:

  • To investigate the effect of Methylphenidate (MPH) on social conformity of value.
  • To explore the role of catecholamines in social learning and conformity.

Main Methods:

  • 38 healthy adult females received either 20mg MPH or placebo.
  • Participants rated faces for trustworthiness, then saw peer ratings, and re-rated faces.
  • A 2-back working-memory task was administered to assess cognitive function.

Main Results:

  • Both groups showed conformity, shifting ratings towards the social norm.
  • The MPH group exhibited twice the conformity effect compared to the placebo group in moderate social conflict.
  • MPH did not influence performance on the working-memory task.

Conclusions:

  • MPH may enhance weak social signals, thereby increasing conformity.
  • This study provides novel evidence for catecholamine mediation in social learning.
  • A neurocognitive mechanism for MPH reducing socially disruptive behavior is proposed.