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Related Experiment Video

Updated: May 25, 2026

Measuring Constipation in a Drosophila Model of Parkinson's Disease

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Published on: September 22, 2023

[Enteric nervous system and Parkinson's disease].

S Paillusson¹, T Lebouvier, H Pouclet

¹Inserm U913, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.

La Revue De Medecine Interne

|February 10, 2012

Summary

Parkinson's disease affects the enteric nervous system, influencing pathology spread and gastrointestinal issues. The enteric nervous system offers a potential source for Parkinson's disease biomarkers.

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An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

Area of Science:

Neuroscience
Gastroenterology
Pathology

Context:

Parkinson's disease (PD) is increasingly recognized as a complex neurodegenerative disorder.
Pathology extends beyond the substantia nigra to affect other neuronal systems.
The enteric nervous system (ENS), located within the gastrointestinal tract, is implicated in PD.

Purpose:

To explore the role of enteric nervous system lesions in the pathological progression of Parkinson's disease, referencing Braak's hypothesis.
To discuss the contribution of the enteric nervous system to gastrointestinal dysfunction observed in Parkinson's disease patients.
To evaluate the potential of the enteric nervous system as a source for novel Parkinson's disease biomarkers.

Summary:

Evidence suggests Parkinson's disease pathology originates in or involves the enteric nervous system.
Enteric nervous system lesions are linked to the characteristic gastrointestinal symptoms and the proposed cephalad spread of pathology in Parkinson's disease.
Biopsies of the enteric nervous system present a unique opportunity for biomarker discovery in Parkinson's disease.

Impact:

Highlights the enteric nervous system's critical role in Parkinson's disease pathogenesis and symptomatology.
Proposes the enteric nervous system as a viable and accessible site for early diagnostic biomarker identification in Parkinson's disease.
Advances understanding of Parkinson's disease as a multicentric disorder with significant gastrointestinal involvement.