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Clinical course and pharmacokinetics following a massive overdose of amphotericin B in a neonate
1Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario.
Abstract:
Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death (1). We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.
Insights
A neonate received a 50-fold overdose of Amphotericin, a common antifungal drug. This case highlights the potential severe adverse effects of Amphotericin toxicity in pediatric patients.
Area of Science:
- Pediatric Pharmacology
- Mycology
- Neonatal Medicine
Background:
- Amphotericin is a primary antifungal agent for pediatric fungal infections.
- Standard therapeutic doses are linked to significant adverse events like nephrotoxicity and hepatotoxicity.
- Overdose risks in neonates are not well-documented.