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Related Experiment Videos

Suicide by captopril overdose.

H Park1, G V Purnell, H G Mirchandani

  • 1Department of Public Health, Office of the Medical Examiner, Philadelphia, PA.

Journal of Toxicology. Clinical Toxicology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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This case report details the first fatal captopril overdose with measured plasma concentration. A 75-year-old male died after ingesting ninety 12.5 mg tablets, highlighting potential risks.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Case Reports

Background:

  • Captopril is an angiotensin-converting enzyme (ACE) inhibitor commonly prescribed for hypertension.
  • Overdose cases are rare, with previous literature documenting only unsuccessful suicide attempts.

Observation:

  • A 75-year-old male ingested approximately 1125 mg of captopril in a suicide attempt.
  • Postmortem plasma captopril concentration was determined to be 60.4 mg/L.

Findings:

  • This is the first reported case of a fatal captopril overdose.
  • The measured plasma concentration in this fatal case provides a new data point for captopril toxicity.

Implications:

  • This case underscores the potential lethality of captopril overdose, even with ACE inhibitors.

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  • Further research into the toxicokinetics and lethal dose of captopril may be warranted.
  • Clinicians should be aware of the potential for severe outcomes in captopril overdose scenarios.