Optical fiber LSPR biosensor prepared by gold nanoparticle assembly on polyelectrolyte multilayer

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Optical Sensors

Background:

• Localized surface plasmon resonance (LSPR) biosensors are crucial for sensitive biomolecule detection.
• Optical fiber-based sensors offer advantages in portability and remote sensing.
• Developing robust and reproducible sensing layers is key for practical applications.

Purpose of the Study:

• To present a novel method for constructing an optical fiber LSPR biosensor.
• To utilize a gold nanoparticle (NP) assembled film as the sensing layer.
• To demonstrate the sensor's performance in terms of sensitivity, reproducibility, and anti-interference.

Main Methods:

• Fabrication of a sensing layer using gold NPs on a polyelectrolyte (PE) multilayer-modified optical fiber.
• Utilizing a trilayer PE structure to achieve a monodisperse gold NP assembled film.
• Characterization of the optical fiber LSPR biosensor's performance.

Main Results:

• A simple, time-saving preparation procedure for the LSPR sensor was established.
• The optical fiber LSPR sensor exhibited higher sensitivity and outstanding reproducibility.
• The sensor demonstrated higher anti-interference ability when responding to antibodies.

Conclusions:

• The developed optical fiber LSPR biosensor is a promising platform for sensitive and reliable biomolecular detection.
• The sensor's high sensitivity, reproducibility, and anti-interference make it suitable for portable immunoassay applications.
• This novel method offers an efficient approach to constructing advanced biosensing devices.