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Mitral cell spike synchrony modulated by dendrodendritic synapse location.

Thomas S McTavish1, Michele Migliore, Gordon M Shepherd

  • 1Department of Neurobiology, School of Medicine, Yale University, New Haven CT, USA.

Frontiers in Computational Neuroscience
|February 10, 2012
PubMed
Summary

Olfactory bulb mitral cells synchronize via granule cell networks. Optimal synchrony depends on balanced synaptic input and specific dendrodendritic synapse locations for effective odor processing.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Olfactory System Research

Background:

  • Mitral cells in the olfactory bulb form dendrodendritic synapses with granule cells.
  • This microcircuit is thought to induce synchrony between mitral cells, crucial for olfactory processing.
  • Mechanisms underlying mitral cell synchrony and the role of synapse location remain unclear.

Purpose of the Study:

  • To investigate how the mitral-granule cell microcircuit synchronizes mitral cells.
  • To explore the impact of dendrodendritic synapse location and mitral cell separation on synchrony.
  • To understand the role of input magnitude balance in mitral cell synchronization.

Main Methods:

  • Development of a reduced circuit model with biophysically realistic multi-compartment mitral and granule cells.
Keywords:
backpropagationdendritic processingmitral cellsolfactionsynchrony

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  • Systematic simulation of varying dendrodendritic synapse locations and mitral cell separations.
  • Analysis of the effect of input magnitude balance on spike rates and phase shifts.

    • Main Results:

    • Mitral cells synchronize via shared granule cells, with optimal synchrony achieved when granule cells form two balanced subsets near mitral cell somas.
    • Balanced input magnitude is crucial for synchrony; the circuit normalizes spike rates and introduces phase shifts in weakly driven cells.
    • The specific distribution of dendrodendritic synaptic clusters is critical for optimal mitral cell spike synchronization.

    Conclusions:

    • The spatial arrangement of dendrodendritic synapses significantly influences mitral cell synchrony.
    • Balanced synaptic input and specific clustering of granule cells are key for effective olfactory signal processing.
    • The mitral-granule cell microcircuit plays a vital role in normalizing and synchronizing mitral cell activity.