Related Experiment Video
Updated: May 25, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi's Sarcoma Associated Herpesvirus Entry into Target Cells
Sayan Chakraborty1, Mohanan Valiya Veettil, Bala Chandran
1H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science North Chicago, IL, USA.
Frontiers in Microbiology
|February 10, 2012
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) uses host cell integrins to initiate infection, triggering signaling pathways crucial for pathogenesis. Understanding these early interactions is key to comprehending KSHV infection and disease development.
Area of Science:
- Virology
- Cell Biology
- Immunology
Background:
- Herpesvirus entry involves host cell receptors and viral glycoproteins.
- Kaposi's sarcoma-associated herpesvirus (KSHV, or HHV-8) infects diverse cell types in vivo and in vitro.
- KSHV's interaction with host cells is critical for understanding its pathogenesis.
Purpose of the Study:
- To discuss the early stages of KSHV infection.
- To identify receptors used by KSHV and clarify outstanding questions.
- To explore future research directions in KSHV pathogenesis.
Main Methods:
- Review of KSHV-host cell interactions.
- Analysis of KSHV entry mechanisms.
- Summary of signaling events triggered by KSHV.
Main Results:
- KSHV is the first herpesvirus shown to interact with integrins on adherent target cells.
- This interaction initiates host cell signaling pathways essential for infection.
- KSHV establishes latency in various cell types.
Conclusions:
- Early KSHV-host cell interactions, particularly with integrins, are vital for infection.
- Understanding KSHV-triggered signaling pathways provides a framework for studying pathogenesis.
- Further research is needed to fully comprehend KSHV pathogenesis.
Related Concept Videos
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
02:33Retroviruses
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...