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Updated: May 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Finding and using evidence that you can trust
1South Asian Cochrane Network and Centre, Tamil Nadu, India. prathap@cmcvellore.ac.in
Abstract:
Much of the evidence-base from research is biased. Systematically assembled, quality-appraised, and appropriately summarised reviews of the effects of interventions from all relevant intervention studies are needed, in order to use research evidence to reliably inform health decisions. The Cochrane Library is an online collection of six searchable, up-to-date, evidence-based databases that is available free to access by anyone in India, thanks to a national subscription purchased by the Indian Council of Medical Research. This valuable resource contains the world's single largest collection of systematic reviews and controlled clinical trials, as well as bibliographic details and records of methodological research, health technology assessments and economic analyses. The robust and transparent methods pioneered and used in Cochrane systematic reviews, and independence from industry funding facilitate the detection of biased, deceptive and fraudulent research, and have earned these reviews the reputation of being trusted sources of evidence to inform health decisions. Cochrane reviews have had considerable impact on academic medicine; have informed health practices, policies and guidelines; improved health outcomes; and saved numerous lives.
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