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Visual monitoring of solid-phase extraction using chromogenic fluorous synthesis supports
1Discovery, Millennium Pharmaceuticals Inc., Cambridge Massachusetts 02139, United States. blackburn@mpi.com
Abstract:
Reductive aminations and further transformations of an azo dye and fluorous tagged aldehyde are described. The intensely colored 2,4-dialkoxybenzyl protected amines undergo Fmoc-based peptide coupling, Suzuki reactions, and sulfonamide formation with product isolation facilitated by visual monitoring of fluorous solid phase extraction. Target compounds are released from the supports in high yields and purities by treatment with trifluoroacetic acid (TFA).
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