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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

[C-reactive protein and non-valvula atrial fibrillation combining with thrombosis]

Yan-yan Jin1, Xiao-ling Zhu, Chun-mei Wang

  • 1Department of Emergency, Capital Medical University, Beijing, China. syh2003@sohu.com

Zhonghua Nei Ke Za Zhi
|February 11, 2012
PubMed

Insights

Elevated C-reactive protein (CRP) and larger left atrium diameter (LAd) are key indicators for thrombosis risk in non-valvular atrial fibrillation patients. These findings highlight inflammation

Area of Science:

  • Cardiology
  • Biomarkers
  • Thrombosis Research

Background:

  • Non-valvular atrial fibrillation (NVAF) poses a significant risk for thromboembolic events.
  • Understanding predictors of thrombosis in NVAF is crucial for patient management.
  • Inflammatory markers like C-reactive protein (CRP) are being investigated for their role.

Purpose of the Study:

  • To investigate the association between plasma C-reactive protein (CRP) levels and the presence of thrombosis in patients with non-valvular atrial fibrillation (NVAF).
  • To identify independent risk factors for thrombosis in NVAF patients.

Main Methods:

  • 154 NVAF patients were categorized into thrombus (n=46) and non-thrombus (n=108) groups based on transesophageal echocardiography (TEE).
  • Plasma CRP, D-dimer, left atrium diameter (LAd), and left ventricular ejection fraction (LVEF) were measured.
  • Logistic regression analysis was employed to determine independent risk factors.

Main Results:

  • The thrombus group exhibited significantly higher CRP levels [(5.77 ± 6.37) mg/L vs (1.73 ± 2.39) mg/L, P = 0.003] and larger LAd [(59.86 ± 10.70) mm vs (47.97 ± 13.19) mm, P < 0.001].
  • Logistic regression identified CRP ≥ 1.33 mg/L (OR 2.856) and LAd ≥ 54.5 mm (OR 4.236) as independent risk factors for thrombosis in NVAF.
  • Lower LVEF was also observed in the thrombus group (P < 0.001).

Conclusions:

  • Plasma CRP and LAd are significant independent risk factors for thrombosis in patients with non-valvular atrial fibrillation.
  • Inflammation, as indicated by CRP, may play a role in the development of thrombosis in NVAF.
  • These markers can aid in risk stratification for thrombotic events in NVAF patients.
Abstract

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