Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Avermectin disrupts blood-brain barrier integrity in zebrafish larvae via the Wnt/β-catenin signaling pathway.

Pesticide biochemistry and physiology·2026
Same author

A study of factors influencing access to MDT among patients with stage III to stage IV colorectal cancer: a national multicenter survey.

Frontiers in oncology·2026
Same author

Success Rate of Adrenal Venous Sampling and the Location of Right Adrenal Vein Orifice: A Retrospective Study.

Journal of clinical hypertension (Greenwich, Conn.)·2026
Same author

Diagnostic and Economic Evaluation of [<sup>18</sup>F]FDG PET/CT Versus MRI for Lymph Node Staging in Nasopharyngeal Carcinoma: Implications for Individualized Upper-Neck-Only Irradiation.

Journal of clinical medicine·2026
Same author

Construction of a risk prediction model for postoperative gastrointestinal dysfunction and prevention in patients with gastrointestinal tumors.

World journal of gastrointestinal surgery·2026
Same author

Efficacy and safety of lenvatinib as adjuvant therapy for hepatocellular carcinoma with vascular invasion after curative resection.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026

Related Experiment Video

Updated: May 25, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

[Correlation between orthostatic hypotension and cardiovascular risks in elderly population].

Zhong-Qiu Lin1, Zhi-Quan Xie, Zi-Qiang Wu

  • 1Department of Geriatrics, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.

Zhonghua Yi Xue Za Zhi
|February 11, 2012
PubMed
Summary

Orthostatic hypotension (OH) significantly increases hospitalization rates and the risk of angina and myocardial infarction in older adults. This condition is a robust predictor of serious cardiovascular events in the elderly population.

Related Experiment Videos

Last Updated: May 25, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Area of Science:

  • Gerontology
  • Cardiology
  • Clinical Medicine

Background:

  • Orthostatic hypotension (OH) is a common condition in older adults.
  • Understanding the link between OH and cardiovascular risks is crucial for geriatric care.

Purpose of the Study:

  • To investigate the correlation between orthostatic hypotension and cardiovascular risks.
  • To determine the association between OH and hospitalization rates in the elderly.

Main Methods:

  • A cohort of 1174 individuals over 65 years old was studied.
  • Orthostatic blood pressure and heart rate were measured after a rest period and upon standing.
  • OH was defined by a significant drop in systolic or diastolic blood pressure upon standing; participants were followed for cardiovascular events.

Main Results:

  • The prevalence of OH was 25.6% in the study cohort.
  • OH was associated with significantly higher rates of all-cause and cardiovascular-related hospitalizations.
  • Individuals with OH had a markedly increased risk of angina and myocardial infarction compared to those without OH.

Conclusions:

  • Orthostatic hypotension is a significant risk factor for cardiovascular events in the elderly.
  • OH is a robust predictor of angina and myocardial infarction, increasing hospitalization rates.