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[Expression of aquaporin-4 during brain edema in rats with thioacetamide-induced acute encephalopathy]

Li-Qing Wang1, Sheng-Mei Zhu, Heng-Jun Zhou

  • 1Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Zhonghua Yi Xue Za Zhi
|February 11, 2012
PubMed
Abstract

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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
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