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Production of Nanofibrillar Patterned Collagen for Tissue Engineering
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Fibrin nanoconstructs: a novel processing method and their use as controlled delivery agents.

G Praveen1, P R Sreerekha, Deepthy Menon

  • 1Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India.

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|February 11, 2012
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Summary

Novel fibrin nanoconstructs (FNCs) were synthesized using a green chemistry approach. These biodegradable FNCs demonstrated sustained release of tacrolimus for both oral and parenteral delivery, showing potential for drug delivery and tissue engineering.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Fibrin nanoconstructs (FNCs) offer potential as drug delivery vehicles.
  • Developing surfactant-free methods for FNC synthesis is crucial for biocompatibility.
  • Tacrolimus is a key immunosuppressant for preventing transplant rejection.

Purpose of the Study:

  • To synthesize and characterize novel fibrin nanoconstructs (FNCs) using a green chemistry approach.
  • To evaluate the potential of FNCs as carriers for tacrolimus delivery.
  • To assess the in vitro and in vivo drug release profiles of tacrolimus-loaded FNCs.

Main Methods:

  • Modified water-in-oil emulsification-diffusion route for FNC synthesis.
  • Characterization of FNCs (morphology, size, stability, degradability).
  • Tacrolimus encapsulation and in vitro/in vivo release studies.

Main Results:

  • High yield synthesis of stable, enzymatically degradable fibrin nanotubes and nanoparticles.
  • Achieved 66% tacrolimus encapsulation efficiency with sustained release over one week at pH 7.4.
  • Demonstrated sustained in vivo drug absorption for both oral and parenteral administration in rats.

Conclusions:

  • Surfactant-free FNCs are effective biodegradable nanocarriers for tacrolimus.
  • FNCs exhibit potential for sustained oral and parenteral drug delivery.
  • These nanostructures may also be useful for delivering growth factors in tissue engineering scaffolds.