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Related Experiment Video

Updated: May 25, 2026

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Published on: February 27, 2026

Reference values for thrombotic markers in children.

Darintr Sosothikul1, Yaowaree Kittikalayawong, Pattramon Aungbamnet

  • 1Hematology and Oncology Division, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dsosothikul@hotmail.com

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|February 11, 2012
PubMed
Summary
This summary is machine-generated.

Pediatric thrombotic disorders require age-specific lab tests. This study establishes reference ranges for key hemostatic parameters in children, revealing significant differences from adults to aid diagnosis.

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Published on: February 14, 2017

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Published on: February 14, 2017

Area of Science:

  • Pediatric Hematology
  • Thrombosis and Hemostasis Research
  • Clinical Diagnostics

Background:

  • Thromboembolic events are a growing concern in pediatric populations.
  • Laboratory diagnosis of pediatric thrombotic disorders differs from adult protocols.
  • Establishing age-specific reference ranges for hemostatic parameters is crucial for accurate diagnosis.

Purpose of the Study:

  • To determine normal reference values for natural anticoagulant parameters in healthy children across different age groups.
  • To compare these pediatric reference values with adult values for key hemostatic factors.
  • To provide a diagnostic reference guide for physicians interpreting hemostatic tests in children with suspected thrombotic disorders.

Main Methods:

  • Plasma samples were collected from 127 healthy children (2 months to 16 years) and 30 adults.
  • Assays were performed for a disintegrin-like and metalloprotease with thrombospondin type 1 domain 13 (ADAMTS-13), von Willebrand factor collagen-binding activity (vWF:CB), tissue factor pathway inhibitor (TFPI), homocysteine, and natural anticoagulants.
  • Children were stratified into four age groups: <1 year, 1-5 years, 6-10 years, and 11-16 years.

Main Results:

  • Significantly lower reference values for ADAMTS-13, homocysteine, and protein C activity were observed in all pediatric age groups compared to adults.
  • Protein C antigen, total protein S, free protein S, and antithrombin III (AT III) were significantly lower in children under 1 year compared to adults.
  • Tissue factor pathway inhibitor (TFPI) levels were significantly higher in all pediatric age groups than in adults, while vWF:CB levels were comparable across all groups.

Conclusions:

  • Significant age-related physiological differences exist in ADAMTS-13, TFPI, homocysteine, and natural anticoagulant levels between children and adults.
  • These findings highlight the necessity of age-specific reference ranges for accurate interpretation of hemostatic parameters in pediatric patients.
  • The established reference data will serve as a valuable guide for clinicians diagnosing thrombotic disorders in children.