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Related Experiment Video

Updated: May 25, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Published on: April 28, 2016

Ghrelin, appetite and critical illness.

Neil E Hill¹, Kevin G Murphy, Mervyn Singer

¹Section of Investigative Medicine, Imperial College London, London, UK.

Current Opinion in Critical Care

|February 11, 2012

Summary

Ghrelin, a gastric hormone, may enhance recovery after critical illness by improving appetite and muscle mass. Further studies are needed to confirm its potential in rehabilitation and reducing lean body mass loss.

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Area of Science:

Intensive care medicine
Gastroenterology
Metabolic research

Background:

Critical illness recovery and rehabilitation are key components of intensive care.
Nutritional interventions and feeding strategies are crucial for patient outcomes.
Ghrelin, a gastric hormone, influences appetite, food intake, and immune function.

Purpose of the Study:

To review the interplay between critical illness, appetite regulation, nutrition, and ghrelin.
To explore ghrelin's potential role in post-critical illness recovery.

Main Methods:

Literature review of recent studies on critical illness, nutrition, and ghrelin.
Analysis of ghrelin's effects on appetite, body composition, and immunomodulation.

Main Results:

Critical illness leads to significant lean body mass loss, with current strategies proving ineffective.
Ghrelin demonstrated potential in reducing protein catabolism in animal models.
Ghrelin improved body composition in human chronic cachectic illnesses.

Conclusions:

Improving recovery from critical illness enhances both short-term and long-term patient outcomes.
Ghrelin may be a valuable tool for enhancing appetite, muscle mass, and rehabilitation post-critical illness.
Further clinical studies are required to validate ghrelin's therapeutic potential in critical care recovery.