Related Experiment Video
Updated: May 25, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Epiphany root canal sealer prepared with resinous solvent is irritating to rat subcutaneous tissues
Élcio Daleffe1, José-Estevam Vieira-Ozório, José-Estevam Sousa-Neto
1School of Dentistry, University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo, Brazil.
Objective:
This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues.
Study Design:
Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solvent (RS); GII, Epiphany prepared with 1 drop of RS and photoactivated; GIII, Epiphany associated with self-etch primer and prepared with 1 drop of RS; GIV, Epiphany associated with self-etch primer, prepared with 1 drop of RS and photoactivated. The filled tubes were implanted into 4 different regions of the dorsum of 20 adult male rats.
Results:
After 7, 14 and 21 days, all groups presented a moderate to severe chronic inflammation, necrosis and foreign-body giant cells. At 42 days, although the intensity of chronic inflammatory reaction decreased, the other features still were observed.
Conclusion:
The Epiphany sealer prepared with the RS was irritating to rat subcutaneous tissues.