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Disorders of sex development

Kun Suk Kim1, Jongwon Kim

  • 1Department of Urology, University of Ulsan College of Medicine, Seoul, Korea.

Korean Journal of Urology
|February 11, 2012
PubMed

Insights

Disorders of Sex Differentiation (DSDs) are rare conditions presenting with ambiguous genitalia at birth. New terminology and individualized, multidisciplinary management are crucial for optimal patient care.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Urology

Background:

  • Ambiguous genitalia at birth present diagnostic and management challenges, historically using outdated and potentially offensive terminology.
  • The term 'intersex' and related terms are being replaced due to their confusing and pejorative connotations.

Purpose of the Study:

  • To introduce the updated terminology for disorders of sex differentiation (DSDs) based on the Chicago Consensus.
  • To provide a balanced perspective on the classification, evaluation, and management of DSDs.
  • To emphasize the need for individualized and multidisciplinary care for DSD patients.

Main Methods:

  • Review of current literature and consensus recommendations regarding DSD terminology and management.
  • Discussion of the Chicago Consensus (2005) and its proposed classification system for DSDs.
  • Outline of a multidisciplinary approach to DSD management, including psychological support.

Main Results:

  • The term Disorders of Sex Differentiation (DSDs) is recommended as an umbrella term for conditions with atypical genitalia development.
  • Classification of DSDs utilizes the karyotype as a prefix.
  • Optimal management requires an individualized, multidisciplinary approach encompassing medical, surgical, and psychological aspects.

Conclusions:

  • The adoption of standardized terminology like DSDs is essential for clear communication and sensitive patient care.
  • Individualized and multidisciplinary management strategies are paramount for addressing the complexity of DSDs.
  • Further research is needed to refine guidelines for the optimal care of individuals with DSDs.

Keywords:
GenitaliaSex differentiation disorders

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