[Study of metabolic characteristics in patients with ischemic heart disease based on the insulin test]

The study was undertaken to examine 68 healthy males and 34 patients with Functional Class I coronary heart disease. The insulin test (fasting intravenous simple insulin, 0.15 U/kg body weight, was given in the morning) was performed. The study was conducted in 3 stages: 1) before, 2) 30 min, and 3) 2 hr after insulin administration. Examination of glycemia and gas exchange revealed changes resulting in impaired energy supply of the body in CHD. In CHD patients, the enhanced glucose uptake after insulin was followed by abnormalities both in aerobic and anaerobic glucose oxidation. The insulin test detected the signs of excessive overtension and diminished reserve potentialities of the sympathetic adrenal system early in CHD.