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Related Experiment Video

Updated: May 25, 2026

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Published on: March 16, 2020

Life-or-death decisions upon axonal damage.

Francesco Roselli¹, Pico Caroni

¹Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, Switzerland.

|February 14, 2012

Summary

Following axonal damage, the CHOP and XBP1 unfolded protein response pathways have opposing effects on neuron survival. Activating the XBP1 pathway shows promise as a neuroprotective strategy.

Area of Science:

Neuroscience
Cellular Biology
Molecular Biology

Background:

Axonal damage is a critical factor in neurological disorders.
The unfolded protein response (UPR) is activated by cellular stress.
Different UPR pathways may have distinct roles in neuronal fate.

Purpose of the Study:

To investigate the differential roles of CHOP and XBP1 UPR pathways in neuronal survival after axonal damage.
To determine the neuroprotective potential of modulating these pathways.

Main Methods:

Utilizing a model of axonal damage.
Analyzing the activation of CHOP and XBP1 pathways.
Assessing neuronal survival rates.
Investigating the effects of pathway manipulation.

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Main Results:

CHOP and XBP1 UPR pathways are differentially activated upon axonal damage.
These pathways exert opposing effects on neuronal survival.
XBP1 activation promotes neuronal survival, while CHOP activation may be detrimental.

Conclusions:

The recruitment and impact of UPR pathways are not uniform following axonal injury.
Modulating the XBP1 pathway represents a potential therapeutic avenue for neuroprotection.