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Breast cancer in pregnancy
Frédéric Amant1, Sibylle Loibl, Patrick Neven
1Multidisciplinary Breast Cancer Center, Leuven Cancer Institute, Katholieke Universiteit Leuven, Belgium. frederic.amant@uzleuven.be
Lancet (London, England)
|February 14, 2012
Summary
Breast cancer in pregnancy can be safely managed with multidisciplinary care, including surgery and chemotherapy after 14 weeks gestation. Careful consideration of radiotherapy is needed due to fetal risks.
Area of Science:
- Oncology
- Maternal-Fetal Medicine
Background:
- Breast cancer diagnosis during pregnancy presents unique challenges for treatment and management.
- Optimal care requires a multidisciplinary approach considering both maternal and fetal well-being.
Purpose of the Study:
- To outline current evidence-based strategies for breast cancer staging and treatment during pregnancy.
- To highlight the safety and efficacy of various treatment modalities in pregnant patients.
Main Methods:
- Review of existing literature on breast cancer management in pregnant individuals.
- Analysis of treatment outcomes based on tumor biology, stage, and gestational age.
Main Results:
- Surgery is feasible across all trimesters.
- Radiotherapy requires careful individual assessment due to potential fetal risks.
- Chemotherapy is increasingly supported from 14 weeks gestation onwards.
- Tamoxifen and trastuzumab are contraindicated during pregnancy.
Conclusions:
- Multidisciplinary management enables safe and effective breast cancer treatment during pregnancy.
- Timely treatment can reduce the incidence of prematurity associated with pregnancy and breast cancer.
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