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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...

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Related Experiment Video

Updated: May 25, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Cardiac dysfunction in the CABG patient.

Sisira Siribaddana1

  • 1Faculty of Medicine Rajarata University, Anuradhapura & Institute for Research & Development, Battaramulla, Sri Lanka. nipuna@stmail.lk

Current Opinion in Pharmacology
|February 14, 2012
PubMed
Summary

Coronary artery bypass grafting (CABG) improves outcomes for ischemic heart disease. This review discusses managing post-CABG myocardial infarction, heart failure, and atrial fibrillation with current and emerging therapies.

Area of Science:

  • Cardiovascular Surgery
  • Cardiac Anesthesia
  • Clinical Cardiology

Background:

  • Coronary artery bypass grafting (CABG) is the gold standard for ischemic heart disease.
  • Key complications include myocardial infarction, heart failure, and atrial fibrillation.
  • Optimal management strategies for these post-CABG complications require further clarification.

Purpose of the Study:

  • To review current evidence on managing post-CABG complications.
  • To explore the role of antiplatelet therapy after CABG.
  • To highlight novel therapeutic approaches for post-CABG heart failure and atrial fibrillation.

Main Methods:

  • Literature review of studies on post-CABG complications.
  • Analysis of evidence regarding aspirin, clopidogrel, prasugrel, and ticagrelor.

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Published on: March 27, 2018

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Last Updated: May 25, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
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  • Evaluation of interventions for myocardial stunning, heart failure, and atrial fibrillation.

    • Main Results:

    • Aspirin timing post-CABG remains debated; ticagrelor may offer benefits over other P2Y12 inhibitors.
    • GIK solutions, modified cardioplegia, and intraoperative techniques may reduce post-CABG heart failure.
    • Intra-aortic balloon pump and ischemic preconditioning show promise for heart failure; upstream therapies for atrial fibrillation are emerging.

    Conclusions:

    • Optimizing antiplatelet therapy and managing myocardial stunning are crucial post-CABG.
    • Proactive management of heart failure and atrial fibrillation can improve patient outcomes.
    • Emerging upstream therapies offer new avenues for preventing and treating common post-CABG complications.