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Published on: May 2, 2025
Fontan operation. Hemodynamic factors associated with postoperative outcomes
Alberto Mendoza1, Leticia Albert, Enrique Ruiz
1Instituto Pediátrico del Corazón, Hospital 12 de Octubre, Madrid, Spain. amendozas.hdoc@salud.madrid.org
Insights
The Fontan operation for univentricular heart disease has low hospital mortality. Preoperative hemodynamic assessment identifies high-risk patients, improving outcomes through interventions.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease Surgery
- Cardiovascular Physiology
Background:
- The Fontan operation is a critical palliative procedure for complex univentricular heart conditions.
- Patients often undergo a bidirectional Glenn procedure before the Fontan operation.
- Understanding clinical and hemodynamic factors is crucial for optimizing Fontan outcomes.
Purpose of the Study:
- To characterize patients with univentricular physiology post-bidirectional Glenn procedure.
- To identify risk factors impacting postoperative outcomes following the Fontan operation.
- To evaluate the role of preoperative assessment in Fontan surgery success.
Main Methods:
- Retrospective analysis of 32 patients undergoing Fontan operation (2000-2009).
- Review of clinical data, catheterization results, and surgical details.
- Statistical analysis to identify predictors of postoperative outcomes.
Main Results:
- Hospital mortality was 3%, with 90% survival at median 44 months.
- Preoperative mean pulmonary artery pressure correlated with late mortality.
- Nakata index, McGoon index, and cardiopulmonary bypass duration were significant predictors of outcome.
- 42% of patients received pre-Fontan interventional catheterization.
Conclusions:
- The Fontan operation demonstrates low hospital mortality.
- Preoperative hemodynamic evaluation aids in selecting high-risk patients.
- Interventional procedures before Fontan surgery can enhance postoperative results.
Introduction And Objectives:
The Fontan operation is usually the final palliative procedure in patients with univentricular heart. The objectives of this study were, firstly, to describe the clinical and haemodynamic characteristics of a group of patients with univentricular physiology who had previously been palliated with a bidirectional Glenn procedure and, secondly, to identify risk factors that can influence postoperative outcomes after the Fontan operation.
Methods:
Retrospective study with 32 patients who underwent a Fontan operation between March 2000 and December 2009. Clinical characteristics, catheterization data, type and duration of surgery were revised and analyzed as predictors of postoperative outcome.
Results:
Hospital mortality was 3%. After a median follow-up of 44 months (interquartile range, 32-79), survival was 90%. Preoperative mean pulmonary artery pressure (measured during catheterization) was correlated with late mortality. Of the remaining variables analyzed, the Nakata and McGoon indices, and duration of cardiopulmonary bypass showed the highest correlations with postoperative outcomes. Interventional catheterization before the Fontan operation was performed in 42% of patients.
Conclusions:
Hospital mortality after the Fontan operation was very low. The performance of a haemodynamic study before the Fontan operation made it possible to select high-risk patients for surgery as well as permitting the performance of interventional procedures that could improve postoperative outcome in these patients.
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