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Related Experiment Video

Updated: May 25, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

[Radiobiology dedicated to endothelium].

S Supiot¹, F Paris

¹Inserm UMR892, centre de recherche en cancérologie Nantes-Angers, 8, quai Moncousu, 44007 Nantes cedex 01, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|February 14, 2012

Summary

Radiotherapy is a common cancer treatment, but resistance and toxicity limit its use. Understanding endothelial cell response to radiation is key to improving cancer therapy effectiveness and reducing side effects.

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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

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Published on: March 14, 2022

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Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Area of Science:

Oncology
Radiation Biology
Cell Biology

Context:

Radiotherapy is a cornerstone in cancer treatment, employed in over 60% of cases for curative or palliative intent.
Treatment efficacy is frequently hampered by intrinsic cancer cell resistance and normal tissue radiation toxicity.
Emerging oncology strategies are expanding focus beyond tumor cells to include non-transformed stromal cells as therapeutic targets.

Purpose:

This review aims to elucidate the role of endothelial cells in modulating tumor and healthy tissue responses to radiotherapy.
It seeks to deepen the understanding of endothelial cell radiosensitivity and its implications for treatment outcomes.
The goal is to provide insights into how endothelial cells influence both tumor control and normal tissue damage.

Summary:

Endothelial cells, prevalent in both tumors and healthy tissues, are increasingly recognized as critical players in radiotherapy.
Their response to radiation significantly impacts the effectiveness of cancer treatment and the development of radiation-induced toxicity.
This review synthesizes current knowledge on endothelial cell behavior post-irradiation, highlighting their dual role in mediating treatment effects.

Impact:

Improved understanding of endothelial cell radiation response can lead to novel therapeutic strategies.
Targeting endothelial cells may enhance tumor radiosensitivity while sparing normal tissues.
This research contributes to the development of more effective and safer radiotherapy protocols for cancer patients.